| Issue date | Song | Artist(s) |
|---|---|---|
| January 2 | "Firework" | Katy Perry |
| January 9 | ||
| January 16 | ||
| January 23 | "Grenade" | Bruno Mars |
| January 30 | ||
| February 6 | ||
| February 13 | ||
| February 20 | ||
| February 27 | "Tonight (I'm Fuckin' You)" | Enrique Iglesias featuring Ludacris and DJ Frank E |
| March 6 | ||
| March 13 | ||
| March 20 | "F**kin' Perfect" | P!nk |
| March 27 | "Born This Way" | Lady Gaga |
| April 3 | "Fuck You" | Cee Lo Green |
| April 10 | "S&M" | Rihanna |
| April 17 | "E.T." | Katy Perry featuring Kanye West |
| April 24 | ||
| May 1 | ||
| May 8 | ||
| May 15 | ||
| May 22 | ||
| May 29 | "Rolling in the Deep" | Adele |
| June 5 | ||
| June 12 |